产品名称
NKp30 Rabbit Polyclonal Antibody
别名
NCR3; 1C7; LY117; Natural cytotoxicity triggering receptor 3; Activating natural killer receptor p30; Natural killer cell p30-related protein; NK-p30; NKp30; CD antigen CD337
蛋白名称
Natural cytotoxicity triggering receptor 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=259197
Human Swissprot No.
O14931
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O14931/entry
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q8CFD9
免疫原
The antiserum was produced against synthesized peptide derived from human NCR3. AA range:104-153
特异性
NKp30 Polyclonal Antibody detects endogenous levels of NKp30 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010],
组织表达
Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.
细胞定位
Cell membrane ; Single-pass type I membrane protein .
信号通路
Natural killer cell mediated cytotoxicity;
功能
function:Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.,polymorphism:A genetic variation in NCR3 is associated with mild malaria suceptibility [MIM:609148].,similarity:Belongs to the natural cytotoxicity receptor (NCR) family.,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,subunit:Interacts with CD3Z.,tissue specificity:Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
