产品名称
NKIAMRE Rabbit Polyclonal Antibody
别名
CDKL3; NKIAMRE; Cyclin-dependent kinase-like 3; Serine/threonine-protein kinase NKIAMRE
蛋白名称
Cyclin-dependent kinase-like 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51265
Human Swissprot No.
Q8IVW4
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8IVW4/entry
Mouse Swissprot No.
Q8BLF2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BLF2
免疫原
The antiserum was produced against synthesized peptide derived from human CDKL3. AA range:291-340
特异性
NKIAMRE Polyclonal Antibody detects endogenous levels of NKIAMRE protein.
稀释度
WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The [NKR]KIAxRE motif seems to be a cyclin-binding region.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.,similarity:Contains 1 protein kinase domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
