产品名称
NK-1R Rabbit Polyclonal Antibody
别名
TACR1; NK1R; TAC1R; Substance-P receptor; SPR; NK-1 receptor; NK-1R; Tachykinin receptor 1
蛋白名称
Substance-P receptor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6869
Human Swissprot No.
P25103
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P25103/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21336
Mouse Swissprot No.
P30548
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P30548
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24807
Rat Swissprot Link
http://www.uniprot.org/uniprot/P14600
免疫原
The antiserum was produced against synthesized peptide derived from human NK1R. AA range:211-260
特异性
NK-1R Polyclonal Antibody detects endogenous levels of NK-1R protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008],
组织表达
Brain,G-protein coupled receptors,Lung,Placenta,
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Calcium;Neuroactive ligand-receptor interaction;
功能
function:This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.,online information:Tachykinin entry,similarity:Belongs to the G-protein coupled receptor 1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
