产品名称
Nicalin Rabbit Polyclonal Antibody
别名
NCLN; Nicalin; Nicastrin-like protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56926
Human Swissprot No.
Q969V3
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q969V3/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=103425
Mouse Swissprot No.
Q8VCM8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VCM8
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=314648
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q5XIA1
免疫原
The antiserum was produced against synthesized peptide derived from human NCLN. AA range:474-523
特异性
Nicalin Polyclonal Antibody detects endogenous levels of Nicalin protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.,similarity:Belongs to the nicastrin family.,subunit:Interacts with NOMO2. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, it probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to the gamma-secretase complex.,tissue specificity:Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.,
组织表达
Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.
细胞定位
Endoplasmic reticulum membrane ; Single-pass membrane protein .
功能
function:May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.,similarity:Belongs to the nicastrin family.,subunit:Interacts with NOMO2. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, it probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to the gamma-secretase complex.,tissue specificity:Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
