产品名称
NHE-8 Rabbit Polyclonal Antibody
别名
SLC9A8; KIAA0939; NHE8; Sodium/hydrogen exchanger 8; Na(+)/H(+) exchanger 8; NHE-8; Solute carrier family 9 member 8
蛋白名称
Sodium/hydrogen exchanger 8
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23315
Human Swissprot No.
Q9Y2E8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9Y2E8/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=77031
Mouse Swissprot No.
Q8R4D1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R4D1
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=311651
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q4L208
免疫原
The antiserum was produced against synthesized peptide derived from human SLC9A8. AA range:451-500
特异性
NHE-8 Polyclonal Antibody detects endogenous levels of NHE-8 protein.
稀释度
WB 1:500 - 1:2000.IHC-p:1:50-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009],
组织表达
Ubiquitous. Strongly expressed in skeletal muscle and kidney.
细胞定位
Golgi apparatus membrane ; Multi-pass membrane protein .
功能
function:Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.,similarity:Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.,tissue specificity:Ubiquitous. Strongly expressed in skeletal muscle and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
