产品名称
NHE-7 Rabbit Polyclonal Antibody
别名
SLC9A7; NHE7; Sodium/hydrogen exchanger 7; Na(+)/H(+) exchanger 7; NHE-7; Solute carrier family 9 member 7
蛋白名称
Sodium/hydrogen exchanger 7
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84679
Human Swissprot No.
Q96T83
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96T83/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=236727
Mouse Swissprot No.
Q8BLV3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BLV3
免疫原
The antiserum was produced against synthesized peptide derived from human SLC9A7. AA range:531-580
特异性
NHE-7 Polyclonal Antibody detects endogenous levels of NHE-7 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a sodium and potassium/ proton antiporter that is a member of the solute carrier family 9 protein family. The encoded protein is primarily localized to the trans-Golgi network and is involved in maintaining pH homeostasis in organelles along the secretory and endocytic pathways. This protein may enhance cell growth of certain breast tumors. This gene is part of a gene cluster on chromosome Xp11.23. A pseudogene of this gene is found on chromosome 12. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012],
组织表达
Ubiquitously expressed.
细胞定位
Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein . Recycling endosome membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein .
功能
function:Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis.,miscellaneous:Is not inhibited by amiloride but by benzamil and quinine.,similarity:Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.,subunit:Interacts with SCAMP1, SCAMP2 and SCAMP5; may participate in its shuttling from trans-Golgi network to recycling endosomes.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
