产品名称
NGFR p75 Rabbit Polyclonal Antibody
别名
NGFR; TNFRSF16; Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD antigen CD271
蛋白名称
Tumor necrosis factor receptor superfamily member 16
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4804
Human Swissprot No.
P08138
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P08138/entry
Mouse Swissprot No.
Q9Z0W1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z0W1
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24596
Rat Swissprot Link
http://www.uniprot.org/uniprot/P07174
免疫原
The antiserum was produced against synthesized peptide derived from human TNR16. AA range:121-170
特异性
NGFR p75 Polyclonal Antibody detects endogenous levels of NGFR p75 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008],
细胞定位
Cell membrane ; Single-pass type I membrane protein . Perikaryon . Cell projection, growth cone . Cell projection, dendritic spine .
信号通路
Cytokine-cytokine receptor interaction;Neurotrophin;
功能
domain:Death domain is responsible for interaction with RANBP9.,domain:The extracellular domain is responsible for interaction with NTRK1.,function:Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.,PTM:N- and O-glycosylated.,PTM:O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.,PTM:Phosphorylated on serine residues.,similarity:Contains 1 death domain.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1 (By similarity). Interacts with LINGO1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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