产品名称
NGF Rabbit Polyclonal Antibody
别名
NGF; NGFB; Beta-nerve growth factor; Beta-NGF
蛋白名称
Beta-nerve growth factor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4803
Human Swissprot No.
P01138
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P01138/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18049
Mouse Swissprot No.
P01139
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P01139
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=310738
Rat Swissprot Link
http://www.uniprot.org/uniprot/P25427
免疫原
The antiserum was produced against synthesized peptide derived from human NGF. AA range:33-82
特异性
NGF Polyclonal Antibody detects endogenous levels of NGF protein.
稀释度
WB 1:500 - 1:2000. IHC-p: 1:100-300 ELISA: 1:20000. IF 1:100-300 Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008],
组织表达
Brain,Epithelium,Eye,Leukocyte,
细胞定位
Secreted . Endosome lumen . ProNGF is endocytosed after binding to the cell surface receptor formed by SORT1 and NGFR. .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;Neurotrophin;
功能
disease:Defects in NGF are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) [MIM:608654]. The hereditary sensory and autonomic neuropathies are a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.,function:Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons.,online information:Nerve growth factor entry,similarity:Belongs to the NGF-beta family.,subunit:Homodimer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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