产品名称
Neuronal PAS1 Rabbit Polyclonal Antibody
别名
NPAS1; BHLHE11; MOP5; PASD5; Neuronal PAS domain-containing protein 1; Neuronal PAS1; Basic-helix-loop-helix-PAS protein MOP5; Class E basic helix-loop-helix protein 11; bHLHe11; Member of PAS protein 5; PAS domain-containing protein 5
蛋白名称
Neuronal PAS domain-containing protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4861
Human Swissprot No.
Q99742
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q99742/entry
Mouse Swissprot No.
P97459
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P97459
免疫原
The antiserum was produced against synthesized peptide derived from human NPAS1. AA range:445-494
特异性
Neuronal PAS1 Polyclonal Antibody detects endogenous levels of Neuronal PAS1 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. Studies of a related mouse gene suggest that it functions in neurons. The exact function of this gene is unclear, but it may play protective or modulatory roles during late embryogenesis and postnatal development. [provided by RefSeq, Jul 2008],
组织表达
Brain,Fetal brain,Hepatoma,
功能
function:May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Interacts with ARNT.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
