产品名称
Neuroglycan C Rabbit Polyclonal Antibody
别名
CSPG5; CALEB; NGC; Chondroitin sulfate proteoglycan 5; Acidic leucine-rich EGF-like domain-containing brain protein; Neuroglycan C
蛋白名称
Chondroitin sulfate proteoglycan 5
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10675
Human Swissprot No.
O95196
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O95196/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29873
Mouse Swissprot No.
Q71M36
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q71M36
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50568
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9ERQ6
免疫原
The antiserum was produced against synthesized peptide derived from human CSPG5. AA range:211-260
特异性
Neuroglycan C Polyclonal Antibody detects endogenous levels of Neuroglycan C protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a proteoglycan that may function as a neural growth and differentiation factor. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011],
组织表达
Restricted to brain (at protein level).
细胞定位
Cell membrane ; Single-pass type I membrane protein . Cell junction, synapse, synaptic cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Golgi apparatus membrane ; Single-pass type I membrane protein . Cell surface . In neurons, localizes to synaptic junctions. Also detected in the endoplasmic reticulum and the Golgi. Partially enriched in lipid rafts. .
功能
developmental stage:Expressed in brain of 3 months, 5 and 10-year-old individuals.,function:May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.,miscellaneous:Different forms of various molecular weight have been observed. Such forms are possibly due to different levels of glycosylation, phosphorylation and/or protein cleavage.,PTM:N-glycosylated.,PTM:O-glycosylated; contains chondroitin sulfate glycans. Part-time proteoglycan, expressed in part as a proteoglycan exhibiting chondroitin sulfate glycans and in part as a non-proteoglycan form. The relative amount of both forms depends on tissues and tissues maturation.,PTM:Phosphorylated; in intracellular and extracellular parts.,similarity:Contains 1 EGF-like domain.,subcellular location:In neurons, localizes to synaptic junctions (By similarity). Also detected in the endoplasmic reticulum and the Golgi (By similarity). Partially enriched in lipid rafts.,subunit:Binds TNR and probably TNC (By similarity). Interacts with ERBB3 and GOPC.,tissue specificity:Restricted to brain (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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