产品名称
Neurexin IIIβ Rabbit Polyclonal Antibody
别名
NRXN3; KIAA0743; Neurexin-3-beta; Neurexin III-beta
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9369
Human Swissprot No.
Q9HDB5
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9HDB5/entry
Mouse Swissprot No.
Q8C985
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8C985
免疫原
Synthesized peptide derived from Neurexin IIIβ . at AA range: 30-110
特异性
Neurexin IIIβ Polyclonal Antibody detects endogenous levels of Neurexin IIIβ protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
NRXN3 (neurexin 3) encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder.
组织表达
Expressed in the blood vessel walls (at protein level).
细胞定位
Membrane ; Single-pass type I membrane protein .
信号通路
Cell adhesion molecules (CAMs);
功能
cell morphogenesis,?cell morphogenesis involved in differentiation,?regulation of neurotransmitter levels,?generation of a signal involved in cell-cell signaling,?neurotransmitter transport,?cell motion,?cell adhesion,?cell-cell signaling,?synaptic transmission,?neurotransmitter secretion,?axonogenesis,?axon guidance,?synaptogenesis,?transmission of nerve impulse,?biological adhesion,?cell projection organization,?neuron differentiation,?neuron projection development,secretion by cell,?cellular component morphogenesis,?cell part morphogenesis,?extracellular structure organization,secretion,?neuron development,?cell morphogenesis involved in neuron differentiation,?neuron projection morphogenesis,?cell projection morphogenesis,?synapse organization,?neurological system process,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
