产品名称
Neurexin I Rabbit Polyclonal Antibody
别名
NRXN1; KIAA0578; Neurexin-1-alpha; Neurexin I-alpha
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9378
Human Swissprot No.
Q9ULB1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9ULB1/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18189
Mouse Swissprot No.
Q9CS84
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CS84
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=60391
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q63372
免疫原
The antiserum was produced against synthesized peptide derived from human NRXN1. AA range:502-551
特异性
Neurexin I Polyclonal Antibody detects endogenous levels of Neurexin I protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
NRXN1 (neurexin 1) encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for NRXN1 in the 3' region. Mutations in NRXN1 are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia.
细胞定位
Cell junction, synapse, presynaptic cell membrane ; Single-pass type I membrane protein .
信号通路
Cell adhesion molecules (CAMs);
功能
cell morphogenesis,?cell morphogenesis involved in differentiation,?cell motion,?cell adhesion,?cell-cell signaling,synaptic transmission,?axonogenesis,?axon guidance,?synaptogenesis,?transmission of nerve impulse,?biological adhesion,?cell projection organization,?neuron differentiation,?neuron projection development,?cellular component morphogenesis,?cell part morphogenesis,?extracellular structure organization,?neuron development,?cell morphogenesis involved in neuron differentiation,?neuron projection morphogenesis,?cell projection morphogenesis,synapse organization,?neurological system process,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
