产品名称
Nesprin-3 Rabbit Polyclonal Antibody
别名
SYNE3; C14orf49; Nesprin-3; Nuclear envelope spectrin repeat protein 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=161176
Human Swissprot No.
Q6ZMZ3
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q6ZMZ3/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=212073
Mouse Swissprot No.
Q4FZC9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q4FZC9
免疫原
The antiserum was produced against synthesized peptide derived from human C14orf49. AA range:169-218
特异性
Nesprin-3 Polyclonal Antibody detects endogenous levels of Nesprin-3 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which theters the nucleus to the cytoskeleton by binding PLEC1/Plectin which can associate with the intermediate filament system.,similarity:Belongs to the nesprin family.,similarity:Contains 1 KASH domain.,similarity:Contains 2 spectrin repeats.,subcellular location:Located at the rough reticulum endoplasmic (RER) in some cells.,subunit:Interacts with actin-binding domain of PLEC1/plectin.,
组织表达
Expressed in aortic endothelial cells (at protein level).
细胞定位
Nucleus outer membrane ; Single-pass type IV membrane protein . Nucleus envelope . Rough endoplasmic reticulum .
功能
function:Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which theters the nucleus to the cytoskeleton by binding PLEC1/Plectin which can associate with the intermediate filament system.,similarity:Belongs to the nesprin family.,similarity:Contains 1 KASH domain.,similarity:Contains 2 spectrin repeats.,subcellular location:Located at the rough reticulum endoplasmic (RER) in some cells.,subunit:Interacts with actin-binding domain of PLEC1/plectin.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
