产品名称
NEDL2 Rabbit Polyclonal Antibody
别名
HECW2; KIAA1301; NEDL2; E3 ubiquitin-protein ligase HECW2; HECT; C2 and WW domain-containing protein 2; NEDD4-like E3 ubiquitin-protein ligase 2
蛋白名称
E3 ubiquitin-protein ligase HECW2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57520
Human Swissprot No.
Q9P2P5
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9P2P5/entry
Mouse Swissprot No.
Q6I6G8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6I6G8
免疫原
The antiserum was produced against synthesized peptide derived from human HECW2. AA range:481-530
特异性
NEDL2 Polyclonal Antibody detects endogenous levels of NEDL2 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 C2 domain.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 2 WW domains.,subunit:Interacts with TP73.,tissue specificity:Predominantly expressed in adult brain, lung and heart.,
组织表达
Predominantly expressed in adult brain, lung and heart.
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton, spindle .
功能
function:E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 C2 domain.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 2 WW domains.,subunit:Interacts with TP73.,tissue specificity:Predominantly expressed in adult brain, lung and heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
