产品名称
NDUFA8 Rabbit Polyclonal Antibody
别名
NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Complex I-19kD; CI-19kD; Complex I-PGIV; CI-PGIV; NADH-ubiquinone oxidoreductase 19 kDa subunit
蛋白名称
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4702
Human Swissprot No.
P51970
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P51970/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=68375
Mouse Swissprot No.
Q9DCJ5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DCJ5
免疫原
The antiserum was produced against synthesized peptide derived from human NDUFA8. AA range:109-158
特异性
NDUFA8 Polyclonal Antibody detects endogenous levels of NDUFA8 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the complex I 19 kDa subunit family. Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays an important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015],
组织表达
Kidney,Lymph,Thalamus,
细胞定位
Mitochondrion inner membrane ; Peripheral membrane protein . Mitochondrion intermembrane space . Mitochondrion .
信号通路
Oxidative phosphorylation;Alzheimer's disease;Parkinson's disease;Huntington's disease;
功能
function:Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.,similarity:Belongs to the complex I NDUFA8 subunit family.,similarity:Contains 2 CHCH domains.,subunit:Complex I is composed of 45 different subunits.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
