产品名称
NDRG4 Rabbit Polyclonal Antibody
别名
NDRG4; BDM1; KIAA1180; Protein NDRG4; Brain development-related molecule 1; N-myc downstream-regulated gene 4 protein; Vascular smooth muscle cell-associated protein 8; SMAP-8
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65009
Human Swissprot No.
Q9ULP0
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9ULP0/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=234593
Mouse Swissprot No.
Q8BTG7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BTG7
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9Z2L9
免疫原
The antiserum was produced against synthesized peptide derived from human NDRG4. AA range:187-236
特异性
NDRG4 Polyclonal Antibody detects endogenous levels of NDRG4 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011],
组织表达
Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells.
细胞定位
Cytoplasm, cytosol .
功能
function:May play a role in the early postnatal development and function of neuronal cells.,similarity:Belongs to the NDRG family.,tissue specificity:Expressed only in brain and heart. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
