产品名称
NDRG2 Rabbit Polyclonal Antibody
别名
NDRG2; KIAA1248; SYLD; Protein NDRG2; N-myc downstream-regulated gene 2 protein; Protein Syld709613
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57447
Human Swissprot No.
Q9UN36
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UN36/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29811
Mouse Swissprot No.
Q9QYG0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QYG0
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=171114
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q8VBU2
免疫原
Synthesized peptide derived from NDRG2 . at AA range: 10-90
特异性
NDRG2 Polyclonal Antibody detects endogenous levels of NDRG2 protein.
稀释度
WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).
细胞定位
Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone . In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). .
功能
developmental stage:Specifically expressed during dendritic cell differentiation (in vitro). Expression is low in fetal brain and increases during brain postnatal development.,disease:Found in pathological brain lesions of Alzheimer disease.,disease:Not expressed or strongly down-regulated in various cancer types, such as astrocytoma, meningioma, liver cancer and pancreatic cancer.,function:May be involved in dendritic cell and neuron differentiation. May have anti-tumor activity.,similarity:Belongs to the NDRG family.,subcellular location:Perinuclear in neurons.,tissue specificity:Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Generally not expressed in tumor cell lines. Isoforms 1 and 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
