产品名称
NDR2 Rabbit Polyclonal Antibody
别名
STK38L; KIAA0965; NDR2; Serine/threonine-protein kinase 38-like; NDR2 protein kinase; Nuclear Dbf2-related kinase 2
蛋白名称
Serine/threonine-protein kinase 38-like
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23012
Human Swissprot No.
Q9Y2H1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9Y2H1/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=232533
Mouse Swissprot No.
Q7TSE6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q7TSE6
免疫原
Synthesized peptide derived from NDR2 . at AA range: 380-460
特异性
NDR2 Polyclonal Antibody detects endogenous levels of NDR2 protein.
稀释度
WB 1:500 - 1:2000.IHC-p:1:50-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L.,function:Involved in the regulation of structural processes in differentiating and mature neuronal cells.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Associated with the actin cytoskeleton.,subunit:Homodimeric S100B binds two molecules of STK38L (By similarity). Interacts with MOB1 and MOB2.,tissue specificity:Ubiquitously expressed with highest levels observed in the thymus.,
组织表达
Ubiquitously expressed with highest levels observed in the thymus.
细胞定位
Cytoplasm. Cytoplasm, cytoskeleton. Membrane. Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane.
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by an upstream kinase. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L.,function:Involved in the regulation of structural processes in differentiating and mature neuronal cells.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Associated with the actin cytoskeleton.,subunit:Homodimeric S100B binds two molecules of STK38L (By similarity). Interacts with MOB1 and MOB2.,tissue specificity:Ubiquitously expressed with highest levels observed in the thymus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
