产品名称
Ndfip1 Rabbit Polyclonal Antibody
别名
NDFIP1; N4WBP5; PSEC0192; PSEC0223; NEDD4 family-interacting protein 1; Breast cancer-associated protein SGA-1M; NEDD4 WW domain-binding protein 5; Putative MAPK-activating protein PM13; Putative NF-kappa-B-activating protein 164; Putative
蛋白名称
NEDD4 family-interacting protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80762
Human Swissprot No.
Q9BT67
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9BT67/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=65113
Mouse Swissprot No.
Q8R0W6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R0W6
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=291609
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q5U2S1
免疫原
Synthesized peptide derived from Ndfip1 . at AA range: 150-230
特异性
Ndfip1 Polyclonal Antibody detects endogenous levels of Ndfip1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung.
细胞定位
Endosome membrane ; Multi-pass membrane protein . Golgi apparatus membrane . Cell junction, synapse, synaptosome . Cell projection, dendrite . Secreted . Detected in exosomes and secreted via the exosomal pathway (PubMed:18819914).
功能
developmental stage:Expressed in fetal brain, kidney and lung.,domain:The WW-binding motifs mediate interaction with NEDD4.,function:May play a role in Golgi structure maintenance.,PTM:Ubiquitinated by NEDD4; mono-, di- and polyubiquitinated forms are detected. Ubiquitination regulates its degradation.,subunit:Interacts with NEDD4. Interacts in vitro with NEDD4L, SR140, WWP2 and ITCH.,tissue specificity:Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
