产品名称
NCKX4 Rabbit Polyclonal Antibody
别名
SLC24A4; NCKX4; Sodium/potassium/calcium exchanger 4; Na(+)/K(+)/Ca(2+)-exchange protein 4; Solute carrier family 24 member 4
蛋白名称
Sodium/potassium/calcium exchanger 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=123041
Human Swissprot No.
Q8NFF2
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8NFF2/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=238384
Mouse Swissprot No.
Q8CGQ8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CGQ8
免疫原
The antiserum was produced against synthesized peptide derived from human SLC24A4. AA range:328-377
特异性
NCKX4 Polyclonal Antibody detects endogenous levels of NCKX4 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010],
组织表达
Expressed abundantly in all regions of the brain, aorta, lung and thymus (PubMed:12379639). Expressed at lower levels in the stomach and intestine (PubMed:12379639).
细胞定位
Cell membrane ; Multi-pass membrane protein . Cytoplasm .
功能
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).,polymorphism:Genetic variations in SLC24A4 are associated with skin/hair/eye pigmentation type 6 (SHEP6) [MIM:210750]. Hair, eye and skin pigmentation are among the most visible examples of human phenotypic variation, with a broad normal range that is subject to substantial geographic stratification. In the case of skin, individuals tend to have lighter pigmentation with increasing distance from the equator. By contrast, the majority of variation in human eye and hair color is found among individuals of European ancestry, with most other human populations fixed for brown eyes and black hair.,similarity:Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.,tissue specificity:Expressed abundantly in all regions of the brain, aorta, lung and thymus. Expressed at lower levels in the stomach and intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
