产品名称
NCKX1 Rabbit Polyclonal Antibody
别名
SLC24A1; KIAA0702; NCKX1; Sodium/potassium/calcium exchanger 1; Na(+)/K(+)/Ca(2+)-exchange protein 1; Retinal rod Na-Ca+K exchanger
蛋白名称
Sodium/potassium/calcium exchanger 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9187
Human Swissprot No.
O60721
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O60721/entry
免疫原
The antiserum was produced against synthesized peptide derived from human SLC24A1. AA range:154-203
特异性
NCKX1 Polyclonal Antibody detects endogenous levels of NCKX1 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. The encoded protein plays an important role in sodium/calcium exchange in retinal rod and cone photoreceptors by mediating the extrusion of one calcium ion and one potassium ion in exchange for four sodium ions. Mutations in this gene may play a role in congenital stationary night blindness. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],
组织表达
Expressed in the retina, particularly in the inner segment, outer and inner nuclear layers, and ganglion cell layer.
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
function:Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).,PTM:The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration.,similarity:Belongs to the sodium/potassium/calcium exchanger family. SLC24A subfamily.,tissue specificity:Found only in the outer segments of retinal rod photoreceptors.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
