产品名称
Nap1 Rabbit Polyclonal Antibody
别名
AZI2; NAP1; 5-azacytidine-induced protein 2; NF-kappa-B-activating kinase-associated protein 1; Nak-associated protein 1; TILP
蛋白名称
5-azacytidine-induced protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64343
Human Swissprot No.
Q9H6S1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9H6S1/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27215
Mouse Swissprot No.
Q9QYP6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QYP6
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=316051
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q4KMA0
免疫原
The antiserum was produced against synthesized peptide derived from human AZI2. AA range:10-59
特异性
Nap1 Polyclonal Antibody detects endogenous levels of Nap1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
AZI2, or NAP1, contributes to the activation of NFKB (see MIM 164011)-dependent gene expression by activating IKK-related kinases, such as NAK (TBK1; MIM 604834) (Fujita et al., 2003 [PubMed 14560022]).[supplied by OMIM, Mar 2008],
组织表达
Widely expressed (PubMed:14560022). Abundant expression seen in the pancreas and testis (PubMed:14560022).
信号通路
RIG-I-like receptor;
功能
function:Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFN-beta promoter activation via TICAM1.,subunit:Interacts with IKBKE, TBK1 and TICAM1.,tissue specificity:Widely expressed. Abundant expression seen in the pancreas and testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
