产品名称
INT4 Rabbit Polyclonal Antibody
别名
Integrator complex subunit 4 (Int4)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.262% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/92105
Human Swissprot No.
Q96HW7
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96HW7/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/101861
Mouse Swissprot No.
Q8CIM8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CIM8
免疫原
Synthesized peptide derived from human INT4 AA range: 10-60
特异性
This antibody detects endogenous levels of INT4 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008],
组织表达
Aorta,Brain,Muscle,Ovary,Uterus,
功能
function:Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.,similarity:Belongs to the Integrator subunit 4 family.,similarity:Contains 8 HEAT repeats.,subunit:Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
