BD-PT2974

Na+/K+-ATPase α2 Rabbit Polyclonal Antibody

ATP1A2; KIAA0778; Sodium/potassium-transporting ATPase subunit alpha-2; Na(+)/K(+) ATPase alpha-2 subunit; Sodium pump subunit alpha-2

常规抗体

ATP1A2

Sodium/potassium-transporting ATPase subunit alpha-2

WB

Human,Mouse,Rat,Monkey

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

477

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=477

P50993

http://www.uniprot.org/uniprotkb/P50993/entry

98660

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=98660

Q6PIE5

http://www.uniprot.org/uniprot/Q6PIE5

24212

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24212

P06686

http://www.uniprot.org/uniprot/P06686

The antiserum was produced against synthesized peptide derived from human ATP1A2. AA range:971-1020

Na+/K+-ATPase α2 Polyclonal Antibody detects endogenous levels of Na+/K+-ATPase α2 protein.

WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

112kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008],

Brain,Leukocyte,Ovary,Placenta,Uterus,

Membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein .

Cardiac muscle contraction;Aldosterone-regulated sodium reabsorption;

catalytic activity:ATP + H(2)O + Na(+)(In) + K(+)(Out) = ADP + phosphate + Na(+)(Out) + K(+)(In).,disease:Defects in ATP1A2 are a cause of alternating hemiplegia of childhood (AHC) [MIM:104290]. AHC is typically distinguished from familial hemiplegic migraine by infantile onset of the symptoms and high prevalence of associated neurological deficits that become increasingly obvious with age.,disease:Defects in ATP1A2 are the cause of familial hemiplegic migraine 2 (FHM2) [MIM:602481]. Familial hemiplegic migraine is a rare, severe, autosomal dominant subtype of migraine characterized by aura and some hemiparesis.,function:This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.,similarity:Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.,subunit:Composed of three subunits: alpha (catalytic), beta and gamma.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.