产品名称
Na+ CP type VIIα Rabbit Polyclonal Antibody
别名
SCN7A; SCN6A; Sodium channel protein type 7 subunit alpha; Putative voltage-gated sodium channel subunit alpha Nax; Sodium channel protein cardiac and skeletal muscle subunit alpha; Sodium channel protein type VII subunit alpha
蛋白名称
Sodium channel protein type 7 subunit alpha
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6332
Human Swissprot No.
Q01118
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q01118/entry
免疫原
The antiserum was produced against synthesized peptide derived from human SCN7A. AA range:771-820
特异性
Na+ CP type VIIα Polyclonal Antibody detects endogenous levels of Na+ CP type VIIα protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011],
细胞定位
Cell membrane ; Multi-pass membrane protein .
功能
domain:The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.,function:Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.,similarity:Belongs to the sodium channel family.,tissue specificity:Heart and uterus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
