产品名称
Na+ CP type IIβ Rabbit Polyclonal Antibody
别名
SCN2B; Sodium channel subunit beta-2
蛋白名称
Sodium channel subunit beta-2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6327
Human Swissprot No.
O60939
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O60939/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=72821
Mouse Swissprot No.
Q56A07
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q56A07
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25349
Rat Swissprot Link
http://www.uniprot.org/uniprot/P54900
免疫原
The antiserum was produced against synthesized peptide derived from human SCN2B. AA range:71-120
特异性
Na+ CP type IIβ Polyclonal Antibody detects endogenous levels of Na+ CP type IIβ protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015],
细胞定位
Membrane; Single-pass type I membrane protein.
功能
function:Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,subunit:The sodium channel consists of a pore-forming alpha subunit, beta-1 and beta-2 subunits. Beta-1 is non-covalently associated with alpha, while beta-2 is covalently linked by disulfide bonds. Interaction with SCN10A and TNR.,tissue specificity:Brain specific.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
