产品名称
MYPT3 Rabbit Polyclonal Antibody
别名
PPP1R16A; MYPT3; Protein phosphatase 1 regulatory subunit 16A; Myosin phosphatase-targeting subunit 3
蛋白名称
Protein phosphatase 1 regulatory subunit 16A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84988
Human Swissprot No.
Q96I34
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96I34/entry
Mouse Swissprot No.
Q923M0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q923M0
免疫原
The antiserum was produced against synthesized peptide derived from human PPP1R16A. AA range:362-411
特异性
MYPT3 Polyclonal Antibody detects endogenous levels of MYPT3 protein.
稀释度
WB 1:500-2000; IF ICC 1:50-200;ELISA 1:2000-20000;IHC-p 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while other MYPTs result in PP1c activation after becoming phosphorylated, the encoded protein is phosphorylated by protein kinase A and then inhibits the catalytic activity of PP1c. [provided by RefSeq, Jul 2016],
组织表达
Lung,Placenta,Spleen,Uterus,
细胞定位
Cell membrane ; Lipid-anchor .
功能
function:Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.,sequence caution:Cloning artifact.,similarity:Contains 5 ANK repeats.,subunit:Binds PP1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
