产品名称
MYL3 Rabbit Polyclonal Antibody
别名
MYL3; Myosin light chain 3; Cardiac myosin light chain 1; CMLC1; Myosin light chain 1; slow-twitch muscle B/ventricular isoform; MLC1SB; Ventricular/slow twitch myosin alkali light chain
蛋白名称
Myosin light chain 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4634
Human Swissprot No.
P08590
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P08590/entry
Mouse Swissprot No.
P09542
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P09542
免疫原
The antiserum was produced against synthesized peptide derived from human MYL3. AA range:71-120
特异性
MYL3 Polyclonal Antibody detects endogenous levels of MYL3 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008],
组织表达
Heart,Skeletal muscle,
细胞定位
cytosol,muscle myosin complex,myosin complex,sarcomere,A band,I band,
信号通路
Cardiac muscle contraction;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy;
功能
disease:Defects in MYL3 are the cause of cardiomyopathy familial hypertrophic type 8 (CMH8) [MIM:608751]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH8 inheritance can be autosomal dominant or recessive.,disease:Defects in MYL3 are the cause of cardiomyopathy hypertrophic with mid-left ventricular chamber type 1 (MVC1) [MIM:608751]. MVC1 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.,function:Regulatory light chain of myosin. Does not bind calcium.,PTM:The N-terminus is blocked.,similarity:Contains 3 EF-hand domains.,subunit:Myosin is an hexamer of 2 heavy chains and 4 light chains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
