产品名称
MYH Rabbit Polyclonal Antibody
别名
MUTYH; MYH; A/G-specific adenine DNA glycosylase; MutY homolog; hMYH
蛋白名称
A/G-specific adenine DNA glycosylase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4595
Human Swissprot No.
Q9UIF7
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UIF7/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=70603
Mouse Swissprot No.
Q99P21
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99P21
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170841
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q8R5G2
免疫原
The antiserum was produced against synthesized peptide derived from human MUTYH. AA range:151-200
特异性
MYH Polyclonal Antibody detects endogenous levels of MYH protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
细胞定位
Nucleus . Mitochondrion .
信号通路
Base excision repair;
功能
cofactor:Binds 1 4Fe-4S cluster. The cluster is not important for the catalytic activity, but which is probably involved in the proper positioning of the enzyme along the DNA strand.,disease:Defects in MUTYH are a cause of autosomal recessive colorectal adenomatous polyposis [MIM:608456].,disease:Defects in MUTYH are a cause of gastric cancer [MIM:137215].,function:Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.,similarity:Belongs to the nth/mutY family.,similarity:Contains 1 nudix hydrolase domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
