产品名称
Mucin 13 Rabbit Polyclonal Antibody
别名
MUC13; DRCC1; RECC; Mucin-13; MUC-13; Down-regulated in colon cancer 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56667
Human Swissprot No.
Q9H3R2
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9H3R2/entry
Mouse Swissprot No.
P19467
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P19467
免疫原
The antiserum was produced against synthesized peptide derived from human MUC13. AA range:421-470
特异性
Mucin 13 Polyclonal Antibody detects endogenous levels of Mucin 13 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Epithelial mucins, such as MUC13, are a family of secreted and cell surface glycoproteins expressed by ductal and glandular epithelial tissues (Williams et al., 2001 [PubMed 11278439]).[supplied by OMIM, Jul 2008],
组织表达
Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.
细胞定位
Cell membrane ; Single-pass type I membrane protein . Apical cell membrane . Secreted . Also exists as a soluble form.
功能
function:Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.,PTM:Cleaved into two subunits, alpha and beta, probably between the first EGF domain and the SEA domain. Beta subunit contains the cytoplasmic tail and alpha subunit the extracellular tail. The homo-oligomerization into dimers is dependent on intrachain disulfide bonds.,PTM:Highly N-glycosylated.,similarity:Contains 1 SEA domain.,similarity:Contains 3 EGF-like domains.,subcellular location:Also exists as a soluble form.,subunit:Homodimer of beta subunits.,tissue specificity:Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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