产品名称
mtTFA Rabbit Polyclonal Antibody
别名
TFAM; TCF6; TCF6L2; Transcription factor A; mitochondrial; mtTFA; Mitochondrial transcription factor 1; MtTF1; Transcription factor 6; TCF-6; Transcription factor 6-like 2
蛋白名称
Transcription factor A mitochondrial
反应种属
Human,Rat,Mouse,,Bovine
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7019
Human Swissprot No.
Q00059
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q00059/entry
Mouse Swissprot No.
P40630
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P40630
免疫原
The antiserum was produced against synthesized peptide derived from human TFAM. AA range:131-180
特异性
mtTFA Polyclonal Antibody detects endogenous levels of mtTFA protein.
稀释度
WB 1:500-2000;IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],
组织表达
Lymphocyte,Pooled,Uterus,
细胞定位
Mitochondrion . Mitochondrion matrix, mitochondrion nucleoid .
信号通路
Stem cell pathway; Protein_Acetylation
功能
function:Involved in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Activates transcription by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA.,similarity:Contains 2 HMG box DNA-binding domains.,subunit:Interacts with TFB1M and TFB2M.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
