产品名称
MST-3 Rabbit Polyclonal Antibody
别名
STK24; MST3; STK3; Serine/threonine-protein kinase 24; Mammalian STE20-like protein kinase 3; MST-3; STE20-like kinase MST3
蛋白名称
Serine/threonine-protein kinase 24
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8428
Human Swissprot No.
Q9Y6E0
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9Y6E0/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=223255
Mouse Swissprot No.
Q99KH8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99KH8
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=361092
Rat Swissprot Link
http://www.uniprot.org/uniprot/B0LT89
免疫原
The antiserum was produced against synthesized peptide derived from human STK24. AA range:319-368
特异性
MST-3 Polyclonal Antibody detects endogenous levels of MST-3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013],
组织表达
Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.
细胞定位
Cytoplasm. Nucleus. Membrane. The truncated form (MST3/N) translocates to the nucleus. Colocalizes with STK38L in the membrane.
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Manganese. Only isoform A requires manganese.,function:Protein kinase that act on both serine and threonine residues.,PTM:Autophosphorylated. Isoform B is activated by phosphorylation by PKA.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
