产品名称
MRP-S27 Rabbit Polyclonal Antibody
别名
MRPS27; KIAA0264; 28S ribosomal protein S27; mitochondrial; MRP-S27; S27mt
蛋白名称
28S ribosomal protein S27 mitochondrial
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23107
Human Swissprot No.
Q92552
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q92552/entry
Mouse Swissprot No.
Q8BK72
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BK72
免疫原
The antiserum was produced against synthesized peptide derived from human MRPS27. AA range:16-65
特异性
MRP-S27 Polyclonal Antibody detects endogenous levels of MRP-S27 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that may be a functional partner of the death associated protein 3 (DAP3). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013],
组织表达
Overexpressed in hepatocellular carcinoma tissues compared with adjacent non-tumoral liver tissues (at protein level) (PubMed:28714366). Ubiquitous (PubMed:22841715).
细胞定位
Cytoplasm . Mitochondrion .
功能
similarity:Contains 2 PPR (pentatricopeptide) repeats.,subunit:Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
