BD-PC0102

Cleaved-Plasma Kallikrein HC (R390) Rabbit Polyclonal Antibody

KLKB1; KLK3; Plasma kallikrein; Fletcher factor; Kininogenin; Plasma prekallikrein

常规抗体

KLKB1

Plasma kallikrein

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

3818

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3818

P03952

http://www.uniprot.org/uniprotkb/P03952/entry

P26262

http://www.uniprot.org/uniprot/P26262

The antiserum was produced against synthesized peptide derived from human KLKB1. AA range:341-390

Cleaved-Plasma Kallikrein HC (R390) Polyclonal Antibody detects endogenous levels of fragment of activated Plasma Kallikrein HC protein resulting from cleavage adjacent to R390.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

45kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016],

Colon,Liver,Plasma,

Secreted.

Complement and coagulation cascades;

catalytic activity:Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.,disease:Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:612423]; also called Fletcher factor deficiency. This disorder is a blood coagulation defect.,function:The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Plasma kallikrein subfamily.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 4 apple domains.,subunit:The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.