产品名称
MRP-L41 Rabbit Polyclonal Antibody
别名
MRPL41; BMRP; MRPL27; RPML27; PIG3; 39S ribosomal protein L41; mitochondrial; L41mt; MRP-L41; 39S ribosomal protein L27 homolog; Bcl-2-interacting mitochondrial ribosomal protein L41; Cell proliferation-inducing gene 3 protein; MRP-L27 homo
蛋白名称
39S ribosomal protein L41 mitochondrial
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64975
Human Swissprot No.
Q8IXM3
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8IXM3/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=107733
Mouse Swissprot No.
Q9CQN7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CQN7
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=296551
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q5BJX1
免疫原
The antiserum was produced against synthesized peptide derived from human MRPL41. AA range:81-130
特异性
MRP-L41 Polyclonal Antibody detects endogenous levels of MRP-L41 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008],
组织表达
Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).
功能
function:Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances TP53/p53 stability, thereby contributing to TP53/p53-induced apoptosis in response to growth-inhibitory condition. Enhances TP53/p53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.,similarity:Belongs to the ribosomal protein L41 family.,subunit:Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with BCL2.,tissue specificity:Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
