产品名称
MRP7 Rabbit Polyclonal Antibody
别名
ABCC10; MRP7; SIMRP7; Multidrug resistance-associated protein 7; ATP-binding cassette sub-family C member 10
蛋白名称
Multidrug resistance-associated protein 7
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=89845
Human Swissprot No.
Q5T3U5
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q5T3U5/entry
Mouse Swissprot No.
Q8R4P9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R4P9
免疫原
The antiserum was produced against synthesized peptide derived from human MRP7. AA range:835-884
特异性
MRP7 Polyclonal Antibody detects endogenous levels of MRP7 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010],
组织表达
[Isoform 1]: Specifically expressed in spleen. ; [Isoform 2]: Widely expressed.
细胞定位
Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein .
功能
function:ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.,similarity:Belongs to the ABC transporter family.,similarity:Belongs to the ABC transporter family. Conjugate transporter (TC 3.A.1.208) subfamily.,similarity:Contains 2 ABC transmembrane type-1 domains.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
.jpg)
