产品名称
MRLC2 Rabbit Polyclonal Antibody
别名
MYL9; MLC2; MRLC1; MYRL2; Myosin regulatory light polypeptide 9; 20 kDa myosin light chain; LC20; MLC-2C; Myosin RLC; Myosin regulatory light chain 2; smooth muscle isoform; Myosin regulatory light chain 9; Myosin regulatory light chain MRL
蛋白名称
Myosin regulatory light polypeptide 9
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
10398/10627
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10398
Human Swissprot No.
P24844/P19105
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P24844/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=98932
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=296313
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q64122
免疫原
The antiserum was produced against synthesized peptide derived from human MRLC2. AA range:3-52
特异性
MRLC2 Polyclonal Antibody detects endogenous levels of MRLC2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Myosin, a structural component of muscle, consists of two heavy chains and four light chains. The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. The encoded protein binds calcium and is activated by myosin light chain kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Smooth muscle tissues and in some, but not all, nonmuscle cells.
细胞定位
Cytoplasm, cytoskeleton . Cytoplasm, cell cortex . Colocalizes with F-actin, MYH9 and PIEZO1 at the actomyosin cortex in myoblasts. .
信号通路
Vascular smooth muscle contraction;Focal adhesion;Tight junction;Leukocyte transendothelial migration;Regulates Actin and Cytoskeleton;
功能
function:Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion.,miscellaneous:This chain binds calcium.,PTM:Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge.,similarity:Contains 3 EF-hand domains.,subunit:Myosin is an hexamer of 2 heavy chains and 4 light chains.,tissue specificity:Smooth muscle tissues and in some, but not all, nonmuscle cells.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
