产品名称
MOR-1 Rabbit Polyclonal Antibody
别名
OPRM1; MOR1; Mu-type opioid receptor; M-OR-1; MOR-1; Mu opiate receptor; Mu opioid receptor; MOP; hMOP
蛋白名称
Mu-type opioid receptor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4988
Human Swissprot No.
P35372
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P35372/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18390
Mouse Swissprot No.
P42866
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P42866
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25601
Rat Swissprot Link
http://www.uniprot.org/uniprot/P33535
免疫原
The antiserum was produced against synthesized peptide derived from human Opioid Receptor. AA range:341-390
特异性
MOR-1 Polyclonal Antibody detects endogenous levels of MOR-1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013],
组织表达
Expressed in brain. Isoform 16 and isoform 17 are detected in brain.
细胞定位
Cell membrane ; Multi-pass membrane protein . Cell projection, axon . Perikaryon . Cell projection, dendrite . Endosome . Is rapidly internalized after agonist binding. .; [Isoform 12]: Cytoplasm .
信号通路
Neuroactive ligand-receptor interaction;
功能
function:Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Receptor for beta-endorphin.,online information:Mu opioid receptor entry,polymorphism:Variant Asp-40 does not show altered binding affinities for most opioid peptides and alkaloids tested, but it binds beta-endorphin, an endogenous opioid that activates the mu opioid receptor, approximately 3 times more tightly than the most common allelic form.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Forms a complex with G(alpha)z/i2 subunits and the RGSZ proteins, RGSZ17 and RGSZ20. The formation of this complex results in mu-opioid receptor desensitization. Interacts with RGSZ17 and RGSZ20.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
