BD-PT2805

Mnk1 Rabbit Polyclonal Antibody

MKNK1; MNK1; MAP kinase-interacting serine/threonine-protein kinase 1; MAP kinase signal-integrating kinase 1; MAPK signal-integrating kinase 1; Mnk1

常规抗体

MKNK1

MAP kinase-interacting serine/threonine-protein kinase 1

WB

Human,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

8569

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8569

Q9BUB5

http://www.uniprot.org/uniprotkb/Q9BUB5/entry

17346

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17346

O08605

http://www.uniprot.org/uniprot/O08605

The antiserum was produced against synthesized peptide derived from human MKNK1. AA range:111-160

Mnk1 Polyclonal Antibody detects endogenous levels of Mnk1 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

51kD

-20°C/1 year

Polyclonal, Rabbit,IgG

MAP kinase interacting serine/threonine kinase 1(MKNK1) Homo sapiens This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012],

Ubiquitous.

[Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm. Nucleus.

MAPK_ERK_Growth;MAPK_G_Protein;Insulin_Receptor;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway.,function:May play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.,PTM:Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with the C-terminal regions of EIF4G1 and EIF4G2. Also binds to dephosphorylated ERK1 and ERK2, and to the p38 kinases.,tissue specificity:Ubiquitous.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.