产品名称
MN1 Rabbit Polyclonal Antibody
别名
MN1; Probable tumor suppressor protein MN1
蛋白名称
Probable tumor suppressor protein MN1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4330
Human Swissprot No.
Q10571
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q10571/entry
免疫原
The antiserum was produced against synthesized peptide derived from human MN1. AA range:821-870
特异性
MN1 Polyclonal Antibody detects endogenous levels of MN1 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed in fetal and adult tissues. Highest expression is observed in fetal brain and skeletal muscle, and adult skeletal muscle.
功能
disease:A chromosomal aberration involving MN1 may be a cause of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with TEL.,disease:Defects in MN1 may be a cause of meningiomas, slowly growing benign tumors derived from the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord. Meningiomas are believed to be the most common primary tumors of the central nervous system in man.,function:May play a role in tumor suppression.,tissue specificity:Ubiquitously expressed. Highest levels in skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
