产品名称
MLKL Rabbit Polyclonal Antibody
别名
MLKL; Mixed lineage kinase domain-like protein
蛋白名称
Mixed lineage kinase domain-like protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=197259
Human Swissprot No.
Q8NB16
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8NB16/entry
Mouse Swissprot No.
Q9D2Y4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D2Y4
免疫原
Synthesized peptide derived from MLKL . at AA range: 40-120
特异性
MLKL Polyclonal Antibody detects endogenous levels of MLKL protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
组织表达
Chondrocyte,Leukocyte,Lymph node,
细胞定位
Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). .
功能
domain:The protein kinase domain is predicted to be catalytically inactive.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
