产品名称
MKP-7 Rabbit Polyclonal Antibody
别名
DUSP16; KIAA1700; MKP7; Dual specificity protein phosphatase 16; Mitogen-activated protein kinase phosphatase 7; MAP kinase phosphatase 7; MKP-7
蛋白名称
Dual specificity protein phosphatase 16
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80824
Human Swissprot No.
Q9BY84
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9BY84/entry
免疫原
The antiserum was produced against synthesized peptide derived from human DUSP16. AA range:571-620
特异性
MKP-7 Polyclonal Antibody detects endogenous levels of MKP-7 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
dual specificity phosphatase 16(DUSP16) Homo sapiens This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010],
组织表达
Bone marrow,Brain,Duodenum,PCR rescued clones,
细胞定位
Cytoplasm. Nucleus. Cytoplasmic vesicle. After dissociation upon AGTR stimulation, re-associates with ARRB2 on endocytic vesicles.
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;
功能
catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Involved in the inactivation of MAP kinases.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.,similarity:Contains 1 rhodanese domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
