BD-PT2773

MKP-2 Rabbit Polyclonal Antibody

DUSP4; MKP2; VH2; Dual specificity protein phosphatase 4; Dual specificity protein phosphatase hVH2; Mitogen-activated protein kinase phosphatase 2; MAP kinase phosphatase 2; MKP-2

常规抗体

DUSP4

Dual specificity protein phosphatase 4

WB

Human,Mouse,Rat,Monkey

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1846

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1846

Q13115

http://www.uniprot.org/uniprotkb/Q13115/entry

319520

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=319520

Q8BFV3

http://www.uniprot.org/uniprot/Q8BFV3

60587

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=60587

Q62767

http://www.uniprot.org/uniprot/Q62767

The antiserum was produced against synthesized peptide derived from human DUSP4. AA range:81-130

MKP-2 Polyclonal Antibody detects endogenous levels of MKP-2 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

44kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been obser

Skin,Uterus,

Nucleus .

MAPK_ERK_Growth;MAPK_G_Protein;

catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.,similarity:Contains 1 rhodanese domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.