产品名称
MIPP Rabbit Polyclonal Antibody
别名
MINPP1; MIPP; Multiple inositol polyphosphate phosphatase 1; 2; 3-bisphosphoglycerate 3-phosphatase; 2,3-BPG phosphatase; Inositol; 1,3,4,5)-tetrakisphosphate 3-phosphatase; Ins(1,3,4,5)P(4) 3-phosphatase
蛋白名称
Multiple inositol polyphosphate phosphatase 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9562
Human Swissprot No.
Q9UNW1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UNW1/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=17330
Mouse Swissprot No.
Q9Z2L6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z2L6
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29688
Rat Swissprot Link
http://www.uniprot.org/uniprot/O35217
免疫原
The antiserum was produced against synthesized peptide derived from human MINPP1. AA range:328-377
特异性
MIPP Polyclonal Antibody detects endogenous levels of MIPP protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009],
组织表达
Widely expressed with highest levels in kidney, liver and placenta.
细胞定位
Endoplasmic reticulum lumen .
信号通路
Inositol phosphate metabolism;
功能
catalytic activity:Myo-inositol hexakisphosphate + H(2)O = myo-inositol pentakisphosphate (mixed isomers) + phosphate.,disease:Defects in MINPP1 may be involved in follicular thyroid tumors development.,function:Acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) (By similarity). May play a role in bone development (endochondral ossification).,tissue specificity:Widely expressed with highest levels in kidney, liver and placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
