产品名称
MGST2 Rabbit Polyclonal Antibody
别名
MGST2; GST2; Microsomal glutathione S-transferase 2; Microsomal GST-2; Microsomal GST-II
蛋白名称
Microsomal glutathione S-transferase 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4258
Human Swissprot No.
Q99735
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q99735/entry
免疫原
Synthesized peptide derived from MGST2 . at AA range: 370-450
特异性
MGST2 Polyclonal Antibody detects endogenous levels of MGST2 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011],
组织表达
Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow (PubMed:8703034). Abundantly expressed in human umbilical vein endothelial cells (at protein level) (PubMed:11322876).
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Microsome membrane ; Multi-pass membrane protein .
信号通路
Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism;
功能
catalytic activity:RX + glutathione = HX + R-S-glutathione.,function:Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.,similarity:Belongs to the MAPEG family.,subunit:Homotrimer.,tissue specificity:Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
