产品名称
MGST1 Rabbit Polyclonal Antibody
别名
MGST1; GST12; MGST; Microsomal glutathione S-transferase 1; Microsomal GST-1; Microsomal GST-I
蛋白名称
Microsomal glutathione S-transferase 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4257
Human Swissprot No.
P10620
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P10620/entry
Mouse Swissprot No.
Q91VS7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91VS7
免疫原
The antiserum was produced against synthesized peptide derived from human MGST1. AA range:42-91
特异性
MGST1 Polyclonal Antibody detects endogenous levels of MGST1 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012],
组织表达
Highly expressed in liver.
细胞定位
Microsome . Mitochondrion outer membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein .
信号通路
Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism;
功能
catalytic activity:RX + glutathione = HX + R-S-glutathione.,enzyme regulation:Activated by N-ethylmaleimide, except in the testis.,function:Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.,similarity:Belongs to the MAPEG family.,subunit:Homotrimer.,tissue specificity:Highly expressed in liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
