产品名称
mGluR5 Rabbit Polyclonal Antibody
别名
GRM5; GPRC1E; MGLUR5; Metabotropic glutamate receptor 5; mGluR5
蛋白名称
Metabotropic glutamate receptor 5
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2915
Human Swissprot No.
P41594
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P41594/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=108071
Mouse Swissprot No.
Q3UVX5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3UVX5
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24418
Rat Swissprot Link
http://www.uniprot.org/uniprot/P31424
免疫原
The antiserum was produced against synthesized peptide derived from human GRM5. AA range:21-70
特异性
mGluR5 Polyclonal Antibody detects endogenous levels of mGluR5 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
glutamate metabotropic receptor 5(GRM5) Homo sapiens This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],
细胞定位
Cell membrane ; Multi-pass membrane protein .
信号通路
Calcium;Neuroactive ligand-receptor interaction;Gap junction;Long-term potentiation;Long-term depression;Huntington's disease;
功能
function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
