BD-PT2744

mGluR-4 Rabbit Polyclonal Antibody

GRM4; GPRC1D; MGLUR4; Metabotropic glutamate receptor 4; mGluR4

常规抗体

GRM4

Metabotropic glutamate receptor 4

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

2914

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2914

Q14833

http://www.uniprot.org/uniprotkb/Q14833/entry

268934

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=268934

Q68EF4

http://www.uniprot.org/uniprot/Q68EF4

24417

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24417

P31423

http://www.uniprot.org/uniprot/P31423

The antiserum was produced against synthesized peptide derived from human mGluR4. AA range:851-900

mGluR-4 Polyclonal Antibody detects endogenous levels of mGluR-4 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

100kD

-20°C/1 year

Polyclonal, Rabbit,IgG

glutamate metabotropic receptor 4(GRM4) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this

Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.

Cell membrane ; Multi-pass membrane protein .

Neuroactive ligand-receptor interaction;Taste transduction;

function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:Interacts with PICK1.,tissue specificity:Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.