产品名称
mGluR-2/3 Rabbit Polyclonal Antibody
别名
GRM2; GPRC1B; MGLUR2; Metabotropic glutamate receptor 2; mGluR2; GRM3; GPRC1C; MGLUR3; Metabotropic glutamate receptor 3; mGluR3
蛋白名称
Metabotropic glutamate receptor 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2912
Human Swissprot No.
Q14416/Q14832
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q14416/entry
Mouse Gene ID
108068/108069
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=108068
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24415
Rat Swissprot No.
P31421/P31422
Rat Swissprot Link
http://www.uniprot.org/uniprot/P31421
免疫原
The antiserum was produced against synthesized peptide derived from human mGluR2/3. AA range:823-872
特异性
mGluR-2/3 Polyclonal Antibody detects endogenous levels of mGluR-2/3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
glutamate metabotropic receptor 2(GRM2) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene
组织表达
Detected in brain cortex (at protein level). Widely expressed in different regions of the adult brain as well as in fetal brain.
细胞定位
Cell membrane; Multi-pass membrane protein. Cell junction, synapse . Cell projection, dendrite .
信号通路
Neuroactive ligand-receptor interaction;
功能
function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:Interacts with GRASP.,tissue specificity:Widely expressed in different regions of the adult brain as well as in fetal brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
