BD-PT2733

MerTK Rabbit Polyclonal Antibody

MERTK; MER; Tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK

常规抗体

MERTK

Tyrosine-protein kinase Mer

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

10461

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10461

Q12866

http://www.uniprot.org/uniprotkb/Q12866/entry

Q60805

http://www.uniprot.org/uniprot/Q60805

The antiserum was produced against synthesized peptide derived from human MERTK. AA range:10-59

MerTK Polyclonal Antibody detects endogenous levels of MerTK protein.

WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

110kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008],

Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.

Cell membrane ; Single-pass type I membrane protein .

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in MERTK are a cause of retinitis pigmentosa (RP) [MIM:268000]. RP that leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.,function:In case of filovirus infection, seems to function as a cell entry factor.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.